In this blogpost you can download Harper's Illustrated Biochemistry (28th Edition) for free in pdf format from the given below download link.
.JPG "Harper's Illustrated Biochemistry (28th)")
Introduction
Authors and publishers are pleased to present the 28th edition of Harper's Illustrated Biochemistry. This edition contains, for the first time, multicolored images, many of which are new, clearly emphasizing the growing complexity of biochemical knowledge. The cover image of Green Fluorescent Protein (GFP), which awards the 2008 Nobel Prize in Chemistry to Martin Chalfie, Roger Y. Tsien and Osama Shimomur, shows that the book emphasizes the development of young bags. Together with its derivatives, GFP plays an expanding role in controlling protein activity in empty cells and tissues and has many applications in cell biology, biochemistry and medicine. In this issue, we regret saying goodbye to longtime author and editor Daryl Granner. In 1983, in preparation for the 20th edition, Daryl was asked to write new chapters on the endocrine system and the molecular mechanism of hormones, which he succeeded in doing. He claimed responsibility for chapters on membranes, protein synthesis, and molecular biology in the 21st edition and wrote an even more informative new chapter in the evolving field of recombinant DNA technology. For the next 25 years, until the 27th edition, Daryl constantly changed his chapters to provide concise, informative descriptions of these rapidly changing, complex areas. Daryl's editorial colleagues expressed gratitude for his many important contributions as a writer, editor and friend, and wished him good luck in his future endeavors. David Bender, Kathleen Botham, Peter Kennelly and Anthony Weil, former co-authors, are now full-time authors. Rob Murray gratefully appreciates the important contributions of Peter Gross, Fred Keeley and Margaret Rand in specific chapters, and thanks Reinhart Reithmeier, Alan Volchuk, and David B. Williams for reviewing and valuable suggestions for revising the chapter. 40 and 46. In addition, Kasra Haghighat and Mohammad Rassouli-Rashti are grateful that they have read and suggested developments in Chapter 54.
Changes in the 28th edition
In line with our goal to provide students with a text that describes and illustrates biochemistry in a comprehensive, concise and easily accessible way, the authors have a lot of new material in this issue. Many new numbers and tables have been added. Each chapter is revised, updated, and rewritten on several occasions — ten to include the latest advances in knowledge and technology that are necessary to understand and practice medicine.
Two new chapters have been added. Chapter 45, entitled "Free Radicals and Antioxidants," describes sources of free radicals; their detrimental effects on DNA, egg whites and lipids; and their role in causing diseases such as cancer and atherosclerosis. The role of antioxidants in combating their harmful effects has been investigated. Chapter 54 entitled "Biochemical case reports" provides a comprehensive presentation of 16 pathophysiological conditions: adenosine deaminase deficiency, Alzheimer's disease, cholera, colorectal cancer, cystic fibrosis, diabetic ketoacidosis, Duchenne muscular dystrophy, hemochromate poisoning, ethanol poisoning. hereditary, hypothyroidism, kwashiorkor (and protein-energy malnutrition), myocardial infarction, obesity, osteoporosis and xeroderma pigmentosum.
Important new areas of medical importance include:
• Impact of the Human Genome Project on various biomedical fields.
• Rewrite the use of enzymes in medical diagnostics.
• New computer-aided drug discovery material.
• Compilation of some conformational diseases. • New materials in advanced glycation end products and their importance in diabetes mellitus.
• New material to link the flu virus to human cells.
• Some big challenges for medicine.
The following topics have been added differently
Extensive coverage by mass spectrometry, an important analytical method in contemporary biochemistry.
• New images showing various aspects of protein structure. Extended coverage of active regions of enzymes and transition states.
• New information on enzyme analysis methods.
Extensive coverage of aspects of enzyme kinetics.
• New information on micro- and silencing RNAs.
• New information on eukaryotic transcription mechanisms, including mRNA biogenesis and the role of nucleosomes.
• Description of miRNA activities.
• New material on Next Generation Sequencing (NGS) platforms. • New material in Chromatin Immunoprecipitation (CHIP) technology and its applications.
• New information on the subcellular localization of important signaling enzymes (kinases, phosphatases).
• New information on how hormones affect gene transcription.
Each chapter begins with a summary of the biomedical meaning of the content and ends with a summary of the main topics covered.
Book organization
After two introductory chapters ("Biochemistry and Medicine" and "Water and pH"), the text is divided into six main parts. All sections and chapters emphasize the medical importance of biochemistry.
Part I deals with the structures and functions of egg proteins and enzymes. Since almost all reactions in cells are catalyzed by enzymes, it is important to understand the exact relationship of enzymes before addressing other topics. This section also includes a chapter on bioinformatics and computational biology and highlights the growing importance of these topics in modern biochemistry, biology and medicine.
Part II explains how various cellular reactions use or release energy, and follows the ways in which carbohydrates and lipids are synthesized and degraded. Many functions of these two types of molecules are also described.
Part III discusses amino acids, their many metabolic batches, some important components of protein catabolism, and the biochemistry of porphyrins and bile dyes.
Part IV describes the structures and functions of nucleotides and nucleic acids and covers topics such as DNA replication and repair, RNA synthesis and modification, protein synthesis, principles of recombinant DNA and genomic technology, and a new understanding of how a gene exregulates pressure.
Part V discusses aspects of extracellular and intracellular communication. Topics include membrane structure and function, the molecular basis of hormone action, and the key signal transduction field. Part VI deals with twelve special topics: nutrition, digestion and absorption; vitamins and minerals; free radicals and antioxidants; intracellular trading and sequencing of egg whites; glycoproteins; extracellular matrix; muscles and cytoskeleton; plasma proteins and immunoglobulins; hemostasis and thrombosis; red and white blood cells; xenobiotic metabolism; and 16 biochemically oriented case reports. The following chapter concludes with a short epilogue describing some of the main challenges for medicine, in which the solution of biochemistry and related fields plays an important role.
Annex I contains a list of laboratory results relevant to the cases discussed in Chapter 54.
Annex II contains a list of useful websites and a list of biochemical journals or journals with sufficient biochemical content.
thanks
The authors thank Michael Weitz for his important role in planning and updating this issue. It's nice to work with him. We are also very grateful to Kim Davis for her highly professional text management, Sherri Souffrance for overseeing production, Elise Langdon for her design and Margaret Webster-Shapiro for her packaging work. We wholeheartedly acknowledge the work of the artists, typesetters and other unknowns who contributed to the twenty-eighth edition of Harper's Illustrated Biochemistry. We are especially grateful to Joanne Jay of Newgen North America for her central role in managing the entire project and to Joseph Varghes of Thomson Digital for her skillful management of the many works of art needed. edition.
Suggestions from students and colleagues around the world will be especially helpful in creating this issue. We look forward to similar posts in the future.