In this blogpost you can download Harper's Illustrated Biochemistry (31th Edition) for free in pdf format from the given below download link.
Introduction
Authors and editors are pleased to announce the 31st edition of Harper's Illustrated Biochemistry. The first edition, entitled Harper's Biochemistry, was published in 1939 under the sole author of Dr. Harper. Harold Harper at the University of California, San Francisco. The book, now titled Harper's Illustrated Biochemistry, continues to provide a concise overview of these aspects of biochemistry most relevant to medical research, as originally intended. Various authors have contributed to the next edition of this medically oriented textbook on biochemistry. This textbook is now 79 years old.
31st edition cover
The illustration on the cover of the 31st edition, which is the protein structure of Zika virus determined with a resolution of 3.8 Å, was generously created and provided by Ray Sun. Support data appeared in: Sirohi D, Chen Z, Sun L, Klose T, Pierson TC, Rossmann MG, Kuhn RJ: "Cryo-EM structure with a resolution of 3.8 A Zika virus protein", Science
2016; 352: 497-470. Along with Zika virus, first discovered in Uganda's Zika Valley, the viruses responsible for yellow fever, West Nile fever, and dengue fever belong to the Flavivridae family of DNA viruses. The figure shows the resolution of the cryo-EM microscope. More importantly, it recognizes the medical significance of Zika virus infection, which puts pregnant women at serious risk for congenital microcephaly and related serious mental disorders. While the Zika virus is mostly transmitted through the bite of an infected mosquito, recent evidence suggests that the Zika virus can also be transmitted to humans under certain conditions. 31st edition changes
As always, Harper's Illustrated Biochemistry continues to emphasize the close link between biochemistry and understanding of illness, pathology and medical practice. Most chapters have been updated to provide readers with the latest relevant information. I replaced this with Chapter 10.
"Bioinformatics and Computational Biology" is common knowledge or available online in most programs and topics (eg, protein-nucleotide sequence comparisons, in silico approaches to drug design). A new alternative, Chapter 10, "Biochemistry of Transition Metals," integrates data from several chapters, especially blood and plasma cells, to broadly cover the adsorption and transport of iron and copper metal ions. Since about one-third of all proteins are metalloproteins, the new Chapter 10 clearly explains the importance and overall permeability of transition metals. Due to overlap with topics such as protein structure and enzyme reaction mechanisms, the new Chapter 10 now follows the three chapters on enzymes as the last chapter of Section II, now renamed Enzymes: Kinetics, Mechanism, regulation and role of transition metals.
booking organization
The 58 chapters of the edition are strongly focused on the medical importance of biochemistry. Topics are organized into eleven main headings. To facilitate the study and facilitate the memorization of the information received, questions follow each section. The bank of answers follows the appendix. The first section provides a brief history of biochemistry and highlights the interrelationships between biochemistry and medicine. Water is discussed, the importance of intracellular pH balance is discussed, and various protein structure needs are addressed.
The second section begins with a chapter on hemoglobin. The following four chapters address the kinetics, mechanism of action, metabolic regulation of enzymes and the role of metal ions in many aspects of intermediate metabolism.
Section III covers bioenergetics and the role of high-energy phosphates in the absorption and transport of energy, the redox reactions involved in biological oxidation and the metabolic details of respiratory energy absorption and oxidative phosphorylation. Section IV discusses carbohydrate metabolism via glycolysis, citric acid cycle, pentose phosphate pathway, glycogen
Metabolism, gluconeogenesis and glycemic control. Section V describes the nature of simple and complex lipids, the transport and storage of lipids, the biosynthesis and degradation of fatty acids and more complex lipids, and the reactions and metabolic regulation of cholesterol biosynthesis and transport in humans.
Section VI discusses protein catabolism, urea biosynthesis, and amino acid catabolism and highlights medically important metabolic disorders associated with their incomplete catabolism. The last chapter deals with the biochemistry of porphyrins and bile pigments.
Section VII first describes the structure and function of nucleotides and nucleic acids, and then discusses DNA replication and repair, RNA synthesis and modification, protein synthesis, principles of recombinant DNA technology, and regulation of gene expression.
Section VIII considers aspects of extracellular and intracellular communication. Specific topics include membrane structure and function, the molecular bases of the actions of hormones, and signal transduction.
Sections IX, X, & XI address fourteen topics of significant medical importance.
Section IX discusses nutrition, digestion, and absorption, micronutrients including vitamins free radicals and antioxidants, glycoproteins, the metabolism of xenobiotics, and clinical biochemistry.
Section X addresses intracellular traffic and the sorting of proteins, the extracellular matrix, muscle and the cytoskeleton, plasma proteins and immunoglobulins, and the biochemistry of red cells and of white cells. Section XI contains haemostasis and coagulation, a review of cancer, the biochemistry of aging and a selection of clinical cases.
Thanks and appreciation
The authors would like to thank Michael Weitz for his role in planning this issue and Peter Boyle for overseeing the preparation for publication. We also thank Surbhi Mittal and Jyoti Shaw of Cenveo Publisher Services for their efforts in managing editing, composition and graphics. We are grateful for the many suggestions and corrections we have received from students and colleagues around the world, especially from Dr. Karthikeyan Pithusami of the All India Institute of Medical Sciences, New Delhi, India.