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Clinical pharmacology is the study of drug use in humans. It is closely linked to therapeutics, which is the study of how diseases are treated. A good understanding of both subjects is essential for safe and effective prescribing, either by doctors or by the more recent (and rapidly increasing) generation of non-medical prescribers.
Drugs of one sort or another have been used by physicians since very ancient times, but not always on the basis of sound science. The first known writings of the use of medicines date back 4000 years or so, to the ancient Egyptians, who used a mixture of minerals and plant-derived concoctions and magic spells to treat disease. Independently, the ancient Indians and Chinese developed their own methods of using of plant- and herb-derived extracts for treating ailments of different kinds, with somewhat variable (and usually not well documented) results. None of these systems for the use of therapeutic substances, collectively often termed ‘materia medica’, were based on an understanding of the underlying basis of disease (pathology) or of the modes of action of these substances (pharmacology).
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