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Since early 2020, the field of immunology has moved to an unexpectedly prominent place in daily life. As SARS-CoV-2 spread around the globe, basic questions about how the immune system combats viruses moved into the forefront of public attention. Why were individual responses to the virus so variable? Why were outcomes in older patients so much more dire than in younger infected individuals? And, most important, how quickly would a vaccine be available, would it provide adequate protection, and for how long? While some questions have been answered, notably observing the most rapid vaccine development in human history, many other questions remain outstanding. Clearly, the need for continued research into basic mechanisms controlling human immunity is undeniable.
Though somewhat overshadowed during the COVID-19 pandemic, there has been a dramatic rise in the use of various other immunotherapies in the years since the last edition of Janeway’s Immunobiology. Multiple methods for manipulating immune responses have significantly altered the practice of clinical medicine, benefiting patients who present with a diagnosis of cancer, autoimmune disease, or chronic inflammatory disorder. In large part, these clinical advances arose from decades of basic research aimed at uncovering the molecules and pathways that regulate immune cells at steady-state conditions or during infection, inflammation, or autoimmunity.
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