Adaptive Design Theory and Implementation Using SAS and R - 1st Ed (2008)

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Overview of Adaptive Design Theory and Implementation Using SAS and R PDF free download:

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Features of Adaptive Design Theory and Implementation Using SAS and R - 1st Ed (2008) PDF free download:

This book is about adaptive clinical trial design and computer implementation. Compared to a classic trial design with static features, an adaptive design allows for changing or modifying the characteristics of a trial based on cumulative information. These modiÖcations are often called adaptations. The word ìadaptationîis so familiar to us because we make adaptations constantly in our daily lives according what we learn over time. Some of the adaptations are necessary for survival, while others are made to improve our quality of life. We should be equally smart in conducting clinical trials by making adaptations based on what we learn as a trial progresses. These adaptations are made because they can improve the e¢ ciency of the trial design, provide earlier remedies, and reduce the time and cost of drug development. An adaptive design is also ethically important. It allows for stopping a trial earlier if the risk to subjects outweighs the beneÖt, or when there is early evidence of e¢ cacy for a safe drug. An adaptive design may allow for randomizing more patients to the superior treatment arms and reducing exposure to ine¢ cacious, but potentially toxic, doses. An adaptive design can also be used to identify better target populations through early biomarker responses.

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