Analyzing Longitudinal Clinical Trial Data (2017) Pdf Free Download

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The statistical theory relevant to analyses of longitudinal clinical trial data is extensive, and applying that theory in practice can be challenging. Therefore, this book focuses on the most relevant and current theory, using practical and easy-to-implement approaches for bringing that theory into routine practice. Emphasis is placed on examples with realistic data, and the programming code to implement the analyses is provided, usually in both SAS and R.

While this book focuses on analytic methods, analyses cannot be considered in isolation. Analyses must be considered as part of a holistic approach to study development and implementation. An industry working group recently proposed a study development process chart that begins with determining objectives, followed by choosing estimands, design, and analyses and assessing sensitivity (Phillips et al. 2016). This book is oriented in accordance with that process. Early chapters focus on objectives, estimands, and design. Subsequent chapters go into detail regarding analyses and sensitivity analyses. The intent of this book is to help facilitate an integrated understanding of key concepts from across the study development process through an example-oriented approach. It is this holistic approach to analysis planning and a focus on practical implementation that sets this text apart from existing texts.

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