Clinical biostatistics (1977) Pdf Free Download

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When I began writing the series of essays called "Clinical biostatistics" in 1970, I thought I would run out of material in about a year. I knew I had some unorthodox things to say and some unconventional viewpoints to develop, but I believed the development would require only six or seven essays. As I became more deeply immersed in biostatistical ideas, however, I constantly found more to do. At every level of contemplation—ranging from the massive logistics of large-scale clinical trials, to the elaborate complexities of "retrospective case- control" studies, to such apparently simple questions as how (and why) to calculate a standard deviation—the world of biostatistics seemed beset with scientific problems that had received unsatisfactory solutions because the -statistics had been given more attention than the bio-. As I began grappling with those challenges, the essays continued to proliferate, until almost 40 of them have now appeared.

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