Exposure-Response Modeling (2015) Pdf Free Download

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Exposure–response (ER) relationships are important in many areas including, but not limited to, pharmacology, epidemiology and drug safety, drug development as a whole, and more recently comparative comparative benefit risk assessments. Determining the relationships by modeling presents challenges to applied statisticians and modelers as well as researchers due to the dynamic nature of both exposure and response. This book covers a wide range

of topics and new developments starting from traditional pharmacokineticpharmacodynamic (PKPD) modeling, and progressing to using measurement error models to treat sequential modeling, fitting models with exposure and response driven by complex dynamics, survival analysis with dynamic exposure history, Bayesian analysis and model-based Bayesian decision analysis, causal inference to eliminate confounding biases, and exposure–response modeling with response-dependent dose/treatment adjustments, known as dynamic treatment regimes, for personalized medicine and treatment adaptation. The book is application oriented, but also gives a systematic view of the concept and methodology in each topic.

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