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Features of Fluorine in Pharmaceutical and Medicinal Chemistry PDF free download:
Fluorine has a distinctive place in the periodic table and has absorbed the attention of numerous scientists over many decades. Fluorine chemistry today is a well-established branch of modern sciences, which has tremendously benefited various research areas from material to medical sciences. The synthesis of fluorinated compounds has been extensively explored. Today, this field of research still stretches to the limit the creativity of chemists eager to develop new concepts for both selective fluorination and clever design and manipulation of fluorinated building blocks. The increased availability of fluorinated compounds has led to insightful studies aimed at deciphering the effects of fluorine substitution on physicochemical properties. Aspects of fluorine chemistry have been competently discussed in numerous books and reviews. This monograph is intended for a broad readership of professionals and researchers particularly interested in life sciences and medicine.
An effort has been made to integrate chemistry, biology, drug discovery and medicine in a way that gives the reader an appreciation of how fluorine has enriched the life sciences in many respects. Molecules substituted with fluorine have improved our understanding of the molecular mechanisms of disease states and are continuously contributing to the advancement of drug discovery and diagnostic imaging. These aspects are covered in this book, which is organised around three sections. The first part provides answers on the fundamental question of how the introduction of fluorine modulates the physicochemical and molecular recognition properties of biologically relevant molecules. This is followed by an in-depth coverage of the impact that fluorine has made on drug discovery and development. The last section gives the reader informative accounts on the use of 19F-spinlabelled and 18F-radiolabelled probes for imaging by nuclear magnetic resonance and positron emission tomography, respectively.
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