In this blog post, You can download Noninferiority Testing in Clinical Trials_ Issues and Challenges (2014) pdf Free download for free in PDF format download with one download.
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Before we share the free PDF download of Modern adaptive randomized clinical trials _ statistical and practical aspects (2016) pdf Free download with you, here are a few important details about this book in case you're interested.
An experimental (or test) treatment is often compared to an active control (or standard of care) instead of a placebo control in a randomized controlled trial for ethical reasons, with the objective to show that the experimental treatment is not inferior to the active control. The number of research articles on noninferiority (NI) testing in clinical trials has increased exponentially over the past 15 years. Five special issues on NI were published by three journals in the mid-2000s: two by Statistics in Medicine (2003, 2006), two by the Journal of Biopharmaceutical Statistics (2004, 2007), and one by the Biometrical Journal (2005). One additional special issue on NI trials was published by Biopharmaceutical Statistics in 2011. In addition, there were two workshops on NI trials in the 2000s: PhRMA (Pharmaceutical Research and Manufacturers of America) Non-Inferiority Workshop in 2002 and the U.S. FDA (Food and Drug Administration)/Industry Workshop in 2007. Last, but not least, numerous short courses and tutorials on NI trials were offered at professional meetings, including four given by me (see the list given in this preface below). The earlier ones were offered at the ICSA (International Chinese Statistical Association) Applied Statistics Symposium in 2002 and the FDA/ Industry Workshop in 2003. These tremendous research efforts in NI trials in the past 15 years have made many advances in this area.
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