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Continuing the tradition, once every half decade, of hosting a major biostatistical meeting, where thought leaders can gather to address scientific issues of current and compelling importance, the organizing committee and sponsors held the Fourth Seattle Symposium on Biostatistics on November 22 and 23, 2010. The topic area for this successful meeting was clinical trials, with focus on the use of biomarkers, issues in multi-regional clinical trials, and identifying and addressing safety signals. The event was sponsored by Axio Research, Bristol-Myers Squibb, Genentech, Novartis and Onyx and was co-sponsored by the UW School of Public Health and the Division of Public Health Sciences at the Fred Hutchinson Cancer Research Center (FHCRC). The symposium featured keynote lectures by Robert O’Neill, Ross Prentice and Robert Temple, as well as invited talks by Jesse Berlin, Christy Chuang-Stein, David DeMets, Bill DuMouchel, Susan Ellenberg, Thomas Fleming, Laurence Freedman, Margaret Pepe, Steve Self, Richard Simon, Bruce Weir, John Whittaker and Janet Wittes. Invited panelists included Jesse Berlin, Bruce Binkowitz, Christy Chuang-Stein, Bill DuMouchel, Susan Ellenberg, Thomas Fleming, Henry Fuchs, Dominic Labriola, Robert O’Neill, Robert Temple and Janet Wittes. There were 200 attendees at the symposium. In addition, more than 100 people attended short courses delivered on November 20 and 21, 2010. At these short courses, “Statistical Design of Sequential Clinical Trials in R” was taught by Scott Emerson and Dan Gillen, “The Use of Genetic Marker Data in Clinical Trials” was taught by Bruce Weir and Patrick Heagerty, “Data Monitoring Committees: A Practical Approach” was taught by Susan Ellenberg, Thomas Fleming and David DeMets, “Statistical Evaluation of Markers for Classification and Prediction” was taught by Margaret Pepe and “Practice Issues in the Conduct and Reporting of Large-Scale Clinical Trials: The Women’s Health Initiative Experience” was taught by Garnet Anderson and Andrea LeCroix.
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