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In recent years, as more and more innovative drug products are going off patent, the search for new medicines that can treat critical and/or lifethreatening diseases has become the center of attention of many pharmaceutical companies and research organizations such as the US National Institutes of Health (NIH). This leads to the study of promising traditional Chinese (herbal) medicines (TCM), especially for those intended for treating critical and/or life-threatening diseases such as cancer. A TCM is defined as a Chinese herbal medicine developed for treating patients with certain diseases as diagnosed by the four Chinese major techniques of inspection, auscultation and olfaction, interrogation, and pulse taking and palpation based on traditional Chinese medical theory of global dynamic balance among the functions/activities of all organs of the body. The development of promising TCMs will benefit patients with critical or life-threatening diseases by providing an alternative for treatment and hopefully for cure. The development of promising TCMs will also enhance the search for personalized medicine because it focuses on the minimization of intrasubject variability for achieving the optimal therapeutic effect within individuals. The development of new treatments (focusing on efficacy) in conjunction with TCMs (focusing on the reduction/release of toxicity) has been the direction of future clinical research for treating critical or life-threatening diseases of many pharmaceutical companies and clinical research organizations.

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