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The patency of the airway is regulated by airways smooth musc1e wh ich is under humoral and neural control, and also by other lung structures inc1uding the chest wall. Airway narrowing is an important defence mechanism against inhaled irritants and partic1es. An abnormal constriction of the bronchial tree, such as in asthma and chronic bronchitis, will result in a diminished capacity of the lungs to oxygenate the blood, which will eventually restriet physical activity and reduce the quality of life. Unfortunately, the prevalence, morbidity and mortality of these lung diseases continue to increase despite the introduction of new medicines and altered treatment guidelines. Consequently research into the regulation of airways smooth musc1e in vitro and in vivo has attracted much interest.
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