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Often, the medical student will cringe at the “drudgery” of the basic science courses and see little connection between a field such as pharmacology and clinical problems. Clinicians, however, often wish they knew more about the basic sciences, because it is through the science that we can begin to understand the complexities of the human body and thus have rational methods of diagnosis and treatment.
Mastering the knowledge in a discipline such as pharmacology is a formidable task. It is even more difficult to retain this information and to recall it when the clinical setting is encountered. To accomplish this synthesis, pharmacology is optimally taught in the context of medical situations, and this is reinforced later during the clinical rotations. The gulf between the basic sciences and the patient arena is wide. Perhaps one way to bridge this gulf is with carefully constructed clinical cases that ask basic science-oriented questions. In an attempt to achieve this goal, we have designed a collection of patient cases to teach pharmacology-related points. More importantly, the explanations for these cases emphasize the underlying mechanisms and relate the clinical setting to the basic science data. The principles are explored rather than overemphasizing rote memorization.
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