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As with other areas of biological research, the progress that has been made over the past 25 years in the field of cell adhesion is impressive. In the late 1970s, the search for specific cell surface receptors for adhesion processes was initiated using mainly biochemical and immunological approaches. Since then, the introduction of novel methods of cellular and molecular biology and powerful techniques for manipulating gene expression in transgenic and knock-out mice have greatly advanced the field. Not only do we now know the precise molecular structure of many of the cell adhesion receptors that were postulated to exist in the early days, but we have a clear picture of their function, and evidence of their involvement in signal transduction. We have also found clues to the role of cell adhesion in normal embryonal development and adult physiology, and we have evidence that disturbance in cell adhesion can cause disease.
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