Endothelin and Its Inhibitors (2001) Pdf Free Download

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Since the demonstration by Furchgott and Zawadzki in 1980 that the vascular endothelium formed a potent vasodilator (now known to be nitric oxide), tens of thousands of researchers have been drawn to the study of endothelial cells and thousands of papers have been published. Of all these publications, however, that by Yanagisawa and coworkers in 1988 reporting the discovery of endothelin must rank as one of the very best. It demonstrated the gene and peptide sequences, the synthetic pathway, and the biological effects of endothelin-l. Many researchers realized the significance of the findings and there was an explosion of endothelin research. 

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