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Cell-penetrating peptides (CPPs), alternatively designated as protein transduction domains (PTDs), Trojan peptides, model amphipathic peptides (MAPs), or membrane translocating sequences (MTSs), have the ability to translocate the cell membrane and gain access to the cellular interior. Unfortunately, we currently lack both a common terminology and a uniform explanation for the penetrative mechanism of CPPs. These deficiences confound the current situation in the field and reflect clearly the uncertainity in defining this novel class of peptides in accordance with modern research achievements. Hence, this book summarizes the diffuse area of CPPs, as we understand the field in late 2005, with the anticipation that a universal terminology together with a defined mechanism of cellular penetration will be forthcoming.
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