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It will shortly be the 100th anniversary of the discovery of heparin by Jay McLean in 1916, so a volume dedicated to the enormous progress that has since been made in the understanding and clinical exploitation of this complex biomolecule is particularly timely. The present volume has the principal aim of recording the current state of affairs concerning the use and study of heparin; in addition, we have tried to record the progress made, particularly within the last 30 years, a period full of incident in this field. For this reason, we begin with a chapter on the history of heparin (Barrowcliffe), before going on to outline what is currently known about its biosynthesis (Carlsson and Kjellen) and the molecular basis for its anticoagulant and antithrombotic activity (Gray et al.)

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