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In the movie The Princess Bride, the hero, Westley, has just been subjected to The Machine, a torture device that sucks years of life out of the victim. Like Westley, who cries and moans in pain in response to Count Rugen’s query, anyone embarking on, or reflecting upon, a multi-year project knows the pathologic feeling of time spent on a lengthy and complex project, whether it is a book, a drug, or a film.
Feature films aspiring for blockbuster status can consume $100 million or more in production costs and 3 years just to get to production stage—all to entertain people for a mere 2 hours. Yet this amount of money pales in comparison to the economic realities of producing a new therapeutic that might address an unmet medical need for thousands or even millions of people. By most measures, developing a new drug in 2015 costs at least ten times more than a blockbuster movie. Three years in production is feature film fiction compared to the industry average of ~14 years for drug development.
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