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Developments over the past few years have revealed the remarkable versatility of RNA in any compartment of the cell, tasks that had been thought to be exclusively in the realm of proteins and even beyond (see the introductory chapter by A. Rich). For example, important aspects of organismal development are controlled by very short, so-called micro (mi)RNAs (Ambros 2004). It became apparent that not only proteins or small molecules could be potential targets or effectors of diagnostic and therapeutic intervention but also various classes of RNA molecules. The chapters in this book provide insight into various promising avenues where RNA and nucleic acid derivatives—including antisense RNAs, miRNAs, and amplification/selection (SELEX)-generated aptamers, as well as ribozymes—are at the threshold of impacting medicine.
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