Transition Metal-Catalyzed Couplings in Process Chemistry (2013) Pdf Free Download

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When faced with life’s common maladies, such as the occasional headache, muscle soreness, or fever, you may have reached for a pain reliever such as Advil, Motrin, or Nuprin. Ibuprofen, the active ingredient in these medicines, was discovered by the Boots Pure Drug Company and patented in the 1960. For several decades, the Boots synthesis would serve as the established method for the industrial manufacture of this pharmaceutical compound (Scheme I.1). This process, which has supplied millions of pounds of ibuprofen throughout the years, comprises six steps and has the disadvantage of generating substantial amounts of industrial waste. Much of the waste stems from an indirect approach to the carboxylic acid moiety through a series of functional group manipulations. From a process safety perspective, this route also suffers from intermediates and reagents containing potentially hazardous, high-energy functional groups such as epoxide 2, oxime 3, and hydroxylamine.

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