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Pathology is the study of disease. The field of pathology emerged from the application of the scientific method to the study of human disease. Thus, pathology as a discipline represents the complimentary intersection of medicine and basic science. Early pathologists were typically practicing physicians who described the various diseases that they treated and made observations related to factors that contributed to the development of these diseases. The description of disease evolved over time from gross observation to microscopic inspection of diseased tissues based upon the light microscope, and more recently to the ultrastructural analysis of disease with the advent of the electron microscope.
As hospital-based and community-based registries of disease emerged, the ability of investigators to identify factors that cause disease and assign risk to specific types of exposures expanded to increase our knowledge of the epidemiology of disease. While descriptive pathology can be dated to the earliest written histories of medicine and the modern practice of diagnostic pathology dates back perhaps 200 years, the elucidation of mechanisms of disease and linkage of disease pathogenesis to specific causative factors emerged more recently from studies in experimental pathology. The field of experimental pathology embodies the conceptual foundation of early pathology – the application of the scientific method to the study of disease – and applies modern investigational tools of cell and molecular biology to advanced animal model systems and studies of human subjects.
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