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Louis Pasteur said, “There are no such things as applied sciences, only applications of science.” The application of scientific advancements over the last two decades has led to a plethora of new sight-saving therapies. It is both illuminating and encouraging to compare the last volume of the Handbook of Experimental Pharmacology devoted to the Pharmacology of the Eye published in 1984 to the current volume. The 1984 version, edited by Marvin Sears, provided a sound physiologic and pharmacologic foundation to guide ophthalmic therapy. The medications that were discussed focused on glaucoma, ocular infections, and ocular inflammatory disease. There was little discussion of therapies for retinal diseases or dry eye, and topics such as sustained-release drug delivery were not discussed.
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