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The conception of this book was inspired by the frequent encounters I had with lay friends and acquaintances when I felt pressed to describe the nature of my work primarily as a surgical pathologist. I often started the description by making an analogy to the process of verdict making in the court. The differentiation between benign and malignant lesions was frequently used as an example in order to give surgical pathologists their proper credit in patient care. The importance of the differentiation, I proclaimed, is analogous to separating petty criminals from desperados who wreaked havoc to the society. When further “confronted” by some inquisitive minds which were interested in how we make the calls, I oftentimes resorted to the citation of the basic features of malignancy (i.e., infiltrative growth pattern, cytological anaplasia) and benign lesions (i.e., encapsulation or circumscription) which medical students learn in their second year pathology course. However, in doing so I knew that I did not do enough justice to our trade.
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